| REVIEW ARTICLE |
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| Year : 2019 | Volume
: 1
| Issue : 1 | Page : 12-19 |
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Multimodal Monitoring Technologies for Pathophysiology and Management of Traumatic Brain Injury
Yujie Chen1, Qianwei Chen1, Jian Sun2, Lijun Zhang3, Liang Tan1, Hua Feng1
1 Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China
2 Department of Neurosurgery, Southwest Hospital, Third Military Medical University; College of Biomedical Engineering, Third Military Medical University, Chongqing, China
3 Department of Neurosurgery, Chongqing Municipal Emergency Medical Center, Chongqing, China
Correspondence Address:
Dr. Hua Feng
Department of Neurosurgery, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Street, Shapingba District, Chongqing 400038
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jtccm.jtccm_2_18
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Despite decades of efforts, severe traumatic brain injury (TBI) is still the leading cause for mortality and immobility of children and young adults worldwide and is a great burden to the health-care system. After injury, the oxygen supply is conventionally considered the monitoring parameter in a neurosurgical Intensive Care Unit. However, the overall mortality rate has only slightly improved since the late twentieth century. Evolving evidence suggests that dysfunction of oxygen utilization might be the underlying pathophysiology of secondary brain injury, which should also be a key parameter for multimodal monitoring and management after severe TBI. In this review, we summarize the current and advanced understanding of multimodal monitoring for severe TBI along with novel noninvasive technologies in this field. By continuously monitoring patients with severe TBI, the use of multimodal monitoring technologies including (but not limited to) computed tomography, cerebral microdialysis, near-infrared spectroscopy, magnetic resonance spectroscopy, high-performance liquid chromatography, and magnetic induction phase shift method will be crucial for observing disease changes such as intracranial pressure and brain tissue oxygen partial pressure as well as developing potential therapeutic strategies after severe TBI.
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