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Year : 2019  |  Volume : 1  |  Issue : 2  |  Page : 48-51

Pragmatic Studies for Acute Kidney Injury in China: Renal Replacement Therapy for Acute Kidney Injury and Sepsis Consensus Report of Acute Disease Quality Initiative XIX

1 William Harvey Research Institute, Adult Critical Care Unit, Royal London Hospital, QueenMary University of London, London, UK
2 Department of MICU, Beijing Union Hospital, Beijing, China
3 Department of Critical Care Medicine, Harbin Medical University the Third Affiliated Hospital, Harbin, China
4 The George Institute for Global Health, Concord Clinical School, Sydney Medical School, NSW, Australia

Correspondence Address:
Dr. John R Prowle
William Harvey Research Institute, Queen Mary University of London, Adult Critical Care Unit, Royal London Hospital, Whitechapel Road, London E1 1BB
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jtccm.jtccm_12_18

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In this article, we report consensus of 19th Acute Disease Quality Initiative (ADQI) conference and pragmatic trial proposals on renal replacement therapy (RRT) for acute kidney injury (AKI)and sepsis. The committee develop a list of key questions for the pragmatic trials. Then a systematic literature search was performed using PubMed and Embase. Finally the group summarized the proposed trials using PICO(Patient, Intervention, Comparator, Outcome). The groups recommended the first step would be a prospective observational study to document the current clinical practice of RRT in ICUs. Then the second stage would be to develop a quality improvement (QI) tools to improve and standardize the RRT practice in ICUs. The committee also proposed the primary outcome and secondary outcomes of the trial. Consensus had been reached for the pragmatic trial of RRT for AKI and sepsis in Chinese ICUs.

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