Desmopressin in Critically Ill Neurosurgical Patients: An Overview

Angie Ching-Gonzalez; Christian Meza-Valle; Karen Muñoz-Báez; Juan Medrano-Carreazo; Amit Agrawal; Rakesh Mishra; Adesh Shrivastava; Tariq Janjua; Luis Rafael Moscote-Salazar

doi:10.4103/jtccm.jtccm_14_20

Users Online: 66

REVIEW ARTICLE

Year : 2020 | Volume : 2 | Issue : 2 | Page : 23-27

Desmopressin in Critically Ill Neurosurgical Patients: An Overview

Angie Ching-Gonzalez¹, Christian Meza-Valle¹, Karen Muñoz-Báez¹, Juan Medrano-Carreazo¹, Amit Agrawal², Rakesh Mishra³, Adesh Shrivastava², Tariq Janjua⁴, Luis Rafael Moscote-Salazar⁵
¹ Center of Biomedical Research, Faculty of Medicine, University of Cartagena, Cartagena, Colombia
² Department of Neurosurgery, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India
³ Department of Neurology, National Institute of Mental Health and Neuro Sciences, Military Hospital Jabalpur, Madhya Pradesh, India
⁴ Regions Hospital, MN, USA
⁵ Center of Biomedical Research, Faculty of Medicine, University of Cartagena, Cartagena, Colombia; Department of Neurology, Paracelsus Medical University, Salzburg, Austria, Australia

Correspondence Address:
Dr. Luis Rafael Moscote-Salazar
Paracelsus Medical University, Salzburg
Australia

Source of Support: None, Conflict of Interest: None

Check

DOI: 10.4103/jtccm.jtccm_14_20

Severely ill neurosurgical patients are those who present with pathologies of the nervous system associated with either a high mortality or that which leaves significant sequelae in those who survive. Desmopressin is a synthetic analog of the antidiuretic hormone that is stored in neurohypophysis. Its function is to decrease urinary volume by increasing reabsorption of water in the convoluted tubules and nephron collectors, additionally increasing the expression of coagulation factor VII and the von Willebrand factor. For this reason, its usefulness in the management of various pathologies has been tested, from coagulopathies to posttraumatic and postsurgical diabetes insipidus. It contributes in improving hyponatremia and in maintaining the balance of fluids and electrolytes in traumatic brain injury and subarachnoid hemorrhage (SAH) patients. It has been additionally studied for its role in the risk of rebleeding in SAH patients and in those with coagulopathies, where its implicated mechanism of action is through platelet anti-aggregation.

[FULL TEXT] [PDF]*

Table of Contents

Similar in PUBMED

Search Pubmed for

Search in Google Scholar for

Related articles

Citation Manager

Access Statistics

Reader Comments

Email Alert *

Add to My List *

* Requires registration (Free)

Article Access Statistics

Viewed	3367

Printed	90

Emailed	0

PDF Downloaded	190

Comments	[Add]

Cited by others	1