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Year : 2021  |  Volume : 3  |  Issue : 1  |  Page : 14

Endogenous Sulfur Dioxide, a Novel Gaseous Transmitter Involved in the Regulation of Inflammatory Responses

1 Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, China
2 Department of Pediatrics, Peking University First Hospital; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing, China

Correspondence Address:
Dr. Junbao Du
Xi-An Men Street No 1, West District, Department of Pediatrics, Peking University First Hospital, Beijing - 100034
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2665-9190.330664

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Endogenous sulfur dioxide (SO2) used to be perceived as a notorious, toxic pollutant of the atmosphere. However, recently several studies revealed that in vivo generated mainly from sulfur-containing amino acids, SO2 serves as an essential novel gasotransmitter involved in the regulation of extensive biological activities. Several studies indicate that endogenous SO2 protects against inflammation by inhibiting the production of inflammatory mediators via different molecular pathways. The present review, therefore, summarized the anti-inflammatory effect of endogenous SO2 and its molecular mechanisms.

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