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Year : 2022  |  Volume : 4  |  Issue : 1  |  Page : 14

Early Clinical Management of Sepsis: Past, Present, and Future

Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA

Correspondence Address:
Dr. Craig M Coopersmith
101 Woodruff Circle, Suite WMB 5105, Atlanta 30322, Georgia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JTCCM-D-22-00016

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Sepsis is a syndrome initiated by an infection in which an aberrant host response to the initiating microbe leads to organ dysfunction, and, all too frequently, mortality. An enormous increase in our understanding of sepsis has occurred over the past 25 years. Unfortunately, this increase has not been matched by successful new therapies, and sepsis treatment continues to be centered on timely antibiotics and supportive care. The Surviving Sepsis Campaign has focused practitioners on bundles for quality improvement and guidelines for bedside management. Adhering to standardized care has been associated with improvements in patient outcome. The mainstays of sepsis management, including diagnosis, fluid resuscitation, antimicrobial management, and vasopressors, are critical to successfully treating patients with sepsis and septic shock and play a major role in determining outcome from sepsis. At the same time, there is increasing recognition that a “one size fits all” model cannot always be the best approach to patient management because of the inherent heterogeneity associated with sepsis, both in terms of initiating microbe and the host response. Further, identifying new targets for therapy may allow for improved outcomes. This review study serves to highlight the past and present facets of early clinical management of septic patients and then illustrate future directions that will hopefully improve outcomes in this common and lethal syndrome.

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