Advanced Search
Users Online: 32
Home
About us
Editorial board
Ahead of print
Current Articles
Search
Archives
Submit article
Instructions
Subscribe
Contacts
Login
» Articles published in the past year
To view other articles click corresponding year from the navigation links on the left side.
All
|
Brief Communication
|
Brief Report
|
Case Report
|
Case Reports
|
Commentary
|
Consensus
|
Consensus Report
|
Editorial
|
Editorials
|
Letter to the Editor
|
Letters to the Editor
|
Meeting Report
|
Original Article
|
Original Articles
|
Perspective
|
Review Article
|
Review Articles
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Show all abstracts
Show selected abstracts
Export selected to
Add to my list
Original Article:
Corticosteroids Utilization in the Management of Critically Ill Coronavirus Disease-2019 Pneumonia
Cheng Yang, Jiahao Zhang, Rongzhang Dou, Zhongyi Sun, Jie Yang, Li He, Nanhui Jiang, Rong Huang, Feng Yuan, Guanfa Xiao, Quan Gan, Qiaofa Lu, Zhiyong Peng, Lianjiu Su
J Transl Crit Care Med
2022, 4:4 (27 January 2022)
DOI
:10.4103/jtccm.JTCCM-D-21-00011
Background:
There are controversies regarding corticosteroids using in coronavirus disease-2019 (COVID-19) pneumonia in the current pandemic.
Objectives:
This study investigates the efficacy and safety profiles of corticosteroids therapy in COVID-19 patients.
Methods:
Retrospective, multicenter study case series of consecutive patients with confirmed COVID-19 infection at the whole hospital from January 1 to March 1, 2020, were enrolled. Demographic, clinical, radiological, laboratory, and treatment data were collected and analyzed. The effect of corticosteroids therapy on death and organ-failure complications of pneumonia were analyzed by logistic regression.
Results:
A total of 470 COVID-19 patients at the whole hospital were enrolled. According to the time of corticosteroids initiation and severity of illness, there were 159 patients stratified into critical ill group and 64% (102 of 159) patients received corticosteroids treatments. Ninety-four percent (166 of 176) of corticosteroids were methylprednisolone. The median cumulative corticosteroids dosage was 300 mg equivalent of methylprednisolone over a median duration of 6 days. Multivariate regression analysis showed that corticosteroids use did not affect the mortality. However, corticosteroids therapy at moderate cumulative doses (total exposure 480 mg to 1200 mg) was associated with deceased occurrence of organ-failure complications in critically ill COVID-19.
Conclusions:
Corticosteroids have no effect to mortality in COVID-19 patients. The moderate cumulative doses of corticosteroids might decrease organ-failure complications in critically ill COVID-19. Further large-scale randomized controlled trials are warranted to confirm our findings, until then use of corticosteroids should be used with caution COVID-19 patients.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Letter to the Editor:
Less is more in Corona Virus Disease 2019
Jingjing Xu, Kai Kang, Fu Li, Dongsheng Fei, Wei Yang, Changsong Wang, Kaijiang Yu
J Transl Crit Care Med
2022, 4:3 (27 January 2022)
DOI
:10.4103/JTCCM-D-21-00019
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Editorial:
Timing for Initiating Renal Replacement Therapy in Patients with Acute Kidney Injury: Late is Better?
Kaijiang Yu
J Transl Crit Care Med
2022, 4:2 (18 January 2022)
DOI
:10.4103/JTCCM-D-21-00025
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Letter to the Editor:
Liberal Versus Conservative Fluid Therapy in COVID-19 Patients: What is the Best Strategy for the Treatment of Critically ill Patients?
José de Jesus Bohorquez-Rivero, Ezequiel García-Ballestas, Tariq M Janjua, Luis Rafael Moscote-Salazar
J Transl Crit Care Med
2022, 4:1 (6 January 2022)
DOI
:10.4103/jtccm.jtccm_1_21
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Advanced Search
Month wise articles
Figures next to the month indicate the number of articles in that month
2022
May
[
1
]
April
[
2
]
March
[
2
]
February
[
1
]
January
[
4
]
2021
December
[
4
]
November
[
4
]
October
[
2
]
September
[
4
]
August
[
4
]
June
[
6
]
2020
December
[
20
]
October
[
9
]
2019
September
[
7
]
January
[
9
]
Sitemap
|
What's New
Feedback
|
Copyright and Disclaimer
|
Privacy Notice
© Scholar Media Publishing Co. Ltd | Published by Wolters Kluwer -
Medknow
Online since 24
th
Dec, 2014